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Phase I/II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme.

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Trial Profile

Phase I/II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme.

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 26 Aug 2024

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At a glance

  • Drugs Vorinostat (Primary) ; Isotretinoin; Temozolomide
  • Indications Anaplastic astrocytoma; Glioblastoma; Glioma; Gliosarcoma
  • Focus Adverse reactions
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 22 Aug 2024 Status changed from active, no longer recruiting to discontinued due to no sponsor funding
    • 29 Oct 2020 Planned End Date changed from 30 Apr 2024 to 20 Apr 2024.
    • 29 Oct 2020 Planned primary completion date changed from 30 Apr 2024 to 20 Apr 2024.

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