A Phase III Trials Program Exploring the Integration of Bevacizumab, Everolimus (RAD001), and Lapatinib Into Current Neoadjuvant Chemotherapy Regimes for Primary Breast Cancer - GeparQuinto

Trial Profile

A Phase III Trials Program Exploring the Integration of Bevacizumab, Everolimus (RAD001), and Lapatinib Into Current Neoadjuvant Chemotherapy Regimes for Primary Breast Cancer - GeparQuinto

Completed
Phase of Trial: Phase III

Latest Information Update: 15 Mar 2018

At a glance

  • Drugs Bevacizumab (Primary) ; Everolimus (Primary) ; Lapatinib (Primary) ; Cyclophosphamide; Docetaxel; Epirubicin; Paclitaxel; Trastuzumab
  • Indications Early breast cancer
  • Focus Adverse reactions; Biomarker; Pharmacogenomic; Registrational; Therapeutic Use
  • Acronyms GeparQuinto
  • Most Recent Events

    • 15 Mar 2018 Primary endpoint (To compare the pCR rates of neoadjuvant treatment in Setting III) has not been met as per the results published in the Journal of Clinical Oncology.
    • 15 Mar 2018 Results (n=620) assessing long term outcomes in patients with HER2-positive tumors published in the Journal of Clinical Oncology
    • 09 Dec 2017 Results of this and other study assessing incidence of brain metastasis in breast cancer patients, presented at the 40th Annual San Antonio Breast Cancer Symposium.
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