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A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Trial of Bapineuzumab (AAB-001, ELN115727) In Patients With Mild to Moderate Alzheimer's Disease Who Are Apolipoprotein E4 Carriers

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Trial Profile

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Trial of Bapineuzumab (AAB-001, ELN115727) In Patients With Mild to Moderate Alzheimer's Disease Who Are Apolipoprotein E4 Carriers

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 14 Sep 2022

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At a glance

  • Drugs Bapineuzumab (Primary)
  • Indications Alzheimer's disease
  • Focus Registrational; Therapeutic Use
  • Sponsors JANSSEN Alzheimer Immunotherapy; Janssen Research & Development
  • Most Recent Events

    • 04 Aug 2022 Results from NCT00574132 and NCT00575055 quantifying the impact of study partner (SP) type on the variance of SP-reported Disability Assessment for Dementia scores , presented at the Alzheimer's Association International Conference 2022
    • 02 Feb 2018 Results of Pooled analysis (n=1512) from this and another phase III trial [CT profile 700023608] assessing amyloid-related imaging abnormalities with edema/effusion treated with bapineuzumab published in the Neurology.
    • 23 Jul 2012 Primary endpoint 'Functional-clinical-response' has not been met.
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