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A Randomised, Double-blind, Placebo-controlled, Single Dose, Dose Escalation Study to Determine the Immunogenicity, Safety and Tolerability of S. Typhi (Ty2 aroC-ssaV-) ZH9 at Doses of 5.0 x 10E9 CFU, 7.5 x 10E9 CFU, 1.1 x 10E10 and 1.7 x 10E10 CFU and 1.7 x 10E10 CFU, Following Oral Administration to Healthy, Typhoid Vaccine naïve Subjects in the USA

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A Randomised, Double-blind, Placebo-controlled, Single Dose, Dose Escalation Study to Determine the Immunogenicity, Safety and Tolerability of S. Typhi (Ty2 aroC-ssaV-) ZH9 at Doses of 5.0 x 10E9 CFU, 7.5 x 10E9 CFU, 1.1 x 10E10 and 1.7 x 10E10 CFU and 1.7 x 10E10 CFU, Following Oral Administration to Healthy, Typhoid Vaccine naïve Subjects in the USA

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 24 Aug 2020

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At a glance

  • Drugs Typhoid vaccine (Primary)
  • Indications Typhoid
  • Focus Adverse reactions; Pharmacodynamics

    • Most Recent Events

    • 23 Feb 2010 Results published in Vaccine.
    • 23 Feb 2010 Primary endpoint 'Seroconversion rate' has been met.
    • 30 Jan 2009 Status changed from recruiting to completed, actual patient number and actual end date added from ClinicalTrials.gov.

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