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A Phase I Study of ABT-888 in Combination With Topotecan Plus Carboplatin for High-Risk Myeloproliferative Disorders and AML Out of Myeloproliferative Disorders

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Trial Profile

A Phase I Study of ABT-888 in Combination With Topotecan Plus Carboplatin for High-Risk Myeloproliferative Disorders and AML Out of Myeloproliferative Disorders

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 14 Mar 2024

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At a glance

  • Drugs Veliparib (Primary) ; Carboplatin; Topotecan
  • Indications Acute myeloid leukaemia; Haematological malignancies; Leukaemia; Myelodysplastic syndromes; Myeloproliferative disorders; Polycythaemia vera; Thrombocytosis
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 27 Jul 2017 Results (n=95) assessing exposure-response analysis to inform the planning of a phase II trial published in the Clinical cancer research: an official journal of the American Association for Cancer Research
    • 18 Mar 2017 Results assessing exposure-response analysis to inform the planning of a phase II trial, presented at the 118th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
    • 22 Aug 2016 Results published in the Clinical cancer research: an official journal of the American Association for Cancer Research
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