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A phase I open label dose escalation study of intravenous aflibercept (AVE0005, vascular endothelial growth factor (VEGF) Trap) in combination with R-CHOP [rituximab + cyclophosphamide + doxorubicin + vincristine + prednisone +methotrexate] administered every 2 weeks or every 3 weeks in patients with non Hodgkin's B-cell lymphoma.

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A phase I open label dose escalation study of intravenous aflibercept (AVE0005, vascular endothelial growth factor (VEGF) Trap) in combination with R-CHOP [rituximab + cyclophosphamide + doxorubicin + vincristine + prednisone +methotrexate] administered every 2 weeks or every 3 weeks in patients with non Hodgkin's B-cell lymphoma.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 Nov 2021

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At a glance

  • Drugs Aflibercept (Primary) ; Cyclophosphamide; Doxorubicin; Methotrexate; Prednisone; Rituximab; Vincristine
  • Indications B-cell lymphoma
  • Focus Adverse reactions; Biomarker
  • Sponsors Sanofi

    • Most Recent Events

    • 04 Jan 2012 Actual end date (Oct 2011) added as reported by ClinicalTrials.gov.
    • 04 Jan 2012 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
    • 10 Mar 2009 Status changed from recruiting to active, no longer recruiting as reported by ClinicalTrials.gov.

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