A PHASE III RANDOMIZED TRIAL OF FOLFOXIRI + BEVACIZUMAB VERSUS FOLFIRI + BEVACIZUMAB AS FIRST- LINE TREATMENT FOR METASTATIC COLORECTAL CANCER

Trial Profile

A PHASE III RANDOMIZED TRIAL OF FOLFOXIRI + BEVACIZUMAB VERSUS FOLFIRI + BEVACIZUMAB AS FIRST- LINE TREATMENT FOR METASTATIC COLORECTAL CANCER

Completed
Phase of Trial: Phase III

Latest Information Update: 13 Mar 2018

At a glance

  • Drugs Bevacizumab (Primary) ; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin
  • Indications Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms TRIBE
  • Most Recent Events

    • 13 Mar 2018 Results of a pooled analysis of five prospective trials ((NCT00719797, NCT02271464, NCT02295930, EudraCT2008-001062-93 and NCT02086656; n=153) assessing prognostic impact of histopathologic parameters, published in the British Journal of Cancer
    • 20 Jan 2018 Results assessing the effect of NER-related single nucleotide polymorphisms to predict oxaliplatin efficacy in FOLFOXIRI regimen in patients with metastatic colorectal cancer, presented at the 2018 Gastrointestinal Cancers Symposium.
    • 20 Jan 2018 Results assessing impact of Tfh cell/ B cell pathway-related genetic variants from FIRE-3 and TRIBE studies presented at the 2018 Gastrointestinal Cancers Symposium
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