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A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Patients With Chronic Heart Failure and Reduced Ejection Fraction

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Trial Profile

A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Patients With Chronic Heart Failure and Reduced Ejection Fraction

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 03 Oct 2025

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At a glance

  • Drugs Sacubitril/valsartan (Primary) ; Enalapril
  • Indications Chronic heart failure
  • Focus Registrational; Therapeutic Use
  • Acronyms PARADIGM-HF
  • Sponsors Novartis; Novartis Pharmaceuticals

Most Recent Events

  • 08 Apr 2024 Results (n=1910) assessing Effects of Sacubitril/Valsartan in Patients with Heart Failure Across the Spectrum of Kidney Risk presented at the 73rd Annual Scientific Session of the American College of Cardiology
  • 20 Dec 2023 Results assessing whether higher BUN/Cr is associated with worse outcomes in patients with chronic HF by deriving data from PARADIGM-HF, ATMOSPHERE & DAPA-HF and PARAGON-HF & I-PRESERVE, published in the European Journal of Heart Failure
  • 13 Nov 2023 Results developing and validating a mathematical model of HFrEF and GDMT treatment based on EMPHASIS-HF, PARADIGM-HF and DAPA-HF, presented at the American Heart Association Scientific Sessions 2023

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