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Cilengitide in Subjects With Newly Diagnosed Glioblastoma and Unmethylated MGMT Gene Promoter - a Multicenter, Open-label Phase II Study, Investigating Two Cilengitide Regimens in Combination With Standard Treatment (Temozolomide With Concomitant Radiation Therapy, Followed by Temozolomide Maintenance Therapy). [The CORE Study]

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Trial Profile

Cilengitide in Subjects With Newly Diagnosed Glioblastoma and Unmethylated MGMT Gene Promoter - a Multicenter, Open-label Phase II Study, Investigating Two Cilengitide Regimens in Combination With Standard Treatment (Temozolomide With Concomitant Radiation Therapy, Followed by Temozolomide Maintenance Therapy). [The CORE Study]

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 16 Jul 2022

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At a glance

  • Drugs Cilengitide (Primary) ; Temozolomide
  • Indications Glioblastoma
  • Focus Therapeutic Use
  • Acronyms CORE
  • Sponsors EMD Serono; Merck KGaA

Most Recent Events

  • 07 Jun 2022 Results of an analysis comparing survival outcome using patient-level data from clinical studies: NCT00943826, NCT00813943, NCT00689221 and real-world data from an institutional dataset at a large academic center presented at the 58th Annual Meeting of the American Society of Clinical Oncology
  • 19 Jan 2016 Pooled analysis of 4 studies (n=1869) including data from this study and 3 other trials (see CTP 700046838, 700038467, 700034867) were published in the Journal of Clinical Oncology.
  • 24 Sep 2013 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov record.

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