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A Randomized, Double-blind, Multi-center Phase III Study of Brivanib Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Subjects With Advanced Hepatocellular Carcinoma (HCC) Who Have Failed or Are Intolerant to Sorafenib: The BRISK PS Study (Brivanib Study in HCC Patients at Risk Post Sorafenib)

Trial Profile

A Randomized, Double-blind, Multi-center Phase III Study of Brivanib Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Subjects With Advanced Hepatocellular Carcinoma (HCC) Who Have Failed or Are Intolerant to Sorafenib: The BRISK PS Study (Brivanib Study in HCC Patients at Risk Post Sorafenib)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Oct 2021

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At a glance

  • Drugs Brivanib alaninate (Primary)
  • Indications Liver cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms BRISK-PS
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 27 Sep 2019 Status changed from discontinued to completed.
  • 18 Sep 2018 This trial has been completed in Belgium, according to European Clinical Trials Database.
  • 17 Aug 2018 Status changed to discontinued as the efficacy endpoint met, however, overall experimental dosing regimen is not considered optimal to support further clinical development in this patient population

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