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A Randomized Double-Blind, Placebo-Controlled Study of Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor-Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole

Trial Profile

A Randomized Double-Blind, Placebo-Controlled Study of Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor-Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 Nov 2021

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At a glance

  • Drugs Everolimus (Primary) ; Exemestane
  • Indications Advanced breast cancer; Bone metastases; HER2 negative breast cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms BOLERO-2
  • Sponsors Novartis; Novartis Pharmaceuticals Corporation

Most Recent Events

  • 22 Sep 2020 Results from NCT00073528 (n=484) and NCT00863655 (n=261 ) developing prognostic model based on PAM50 and clinical variables (PAM50MET) for metastatic HER2-negative breast cancer, published in the Clinical Cancer Research
  • 31 May 2020 Results (n=510) assessing the prognostic/predictive ability of serum biomarker, presented at the 56th Annual Meeting of the American Society of Clinical Oncology.
  • 09 Dec 2017 Results assessing the prognostic and predictive ability of activin A (n=513) presented at the 40th Annual San Antonio Breast Cancer Symposium

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