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An Open-Label, Randomized, Parallel-Group Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With Rituximab, Cyclophosphamide, Vincristine, and Prednisone (R-CVP) or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL).

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Trial Profile

An Open-Label, Randomized, Parallel-Group Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With Rituximab, Cyclophosphamide, Vincristine, and Prednisone (R-CVP) or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL).

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 Nov 2021

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At a glance

  • Drugs Bendamustine (Primary) ; Cyclophosphamide; Doxorubicin; Prednisone; Rituximab; Vincristine
  • Indications B-cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms BRIGHT
  • Sponsors Cephalon; Teva Branded Pharmaceutical Products R&D

Most Recent Events

  • 27 Feb 2019 Results assessing long term follow up data of BRIGHT study published in the Journal of Clinical Oncology
  • 13 Jun 2017 Status changed from active, no longer recruiting to completed.
  • 25 May 2017 According to a Sarah Cannon Research Institute media release, data from the study will be presented at the American Society of Clinical Oncology's 2017 Annual Meeting.

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