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Phase 2 Study of Panitumumab Plus Irinotecan Followed by Panitumumab Plus AMG 479 in Subjects With Metastatic Colorectal Carcinoma Expressing Wild Type KRAS and Refractory to Oxaliplatin-or Irinotecan- and Oxaliplatin-Containing Regimens to Evaluate Mechanisms of Acquired Resistance to Panitumumab

Trial Profile

Phase 2 Study of Panitumumab Plus Irinotecan Followed by Panitumumab Plus AMG 479 in Subjects With Metastatic Colorectal Carcinoma Expressing Wild Type KRAS and Refractory to Oxaliplatin-or Irinotecan- and Oxaliplatin-Containing Regimens to Evaluate Mechanisms of Acquired Resistance to Panitumumab

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 23 Jul 2024

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At a glance

  • Drugs Ganitumab (Primary) ; Panitumumab (Primary) ; Irinotecan
  • Indications Colorectal cancer
  • Focus Pharmacogenomic; Therapeutic Use
  • Sponsors Amgen; NantBioScience
  • Most Recent Events

    • 04 Sep 2017 Results (n=74) of dynamic molecular analysis and clinical correlates of tumour evolution, published in the Annals of Oncology Journal.
    • 13 Jan 2014 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
    • 16 Jan 2013 Planned end date changed from 1 Oct 2014 to 1 Apr 2013 as reported by ClinicalTrials.gov.

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