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Phase III Study of Chemotherapy in Combination With ATRA With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia and NPM1 Gene Mutation

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Trial Profile

Phase III Study of Chemotherapy in Combination With ATRA With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia and NPM1 Gene Mutation

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Jan 2024

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At a glance

  • Drugs Gemtuzumab ozogamicin (Primary) ; Cytarabine; Etoposide; Idarubicin; Pegfilgrastim; Tretinoin
  • Indications Acute myeloid leukaemia
  • Focus Registrational; Therapeutic Use
  • Most Recent Events

    • 12 Dec 2023 Results assessing the genomic landscape and leukemogenic trajectories in a large cohort of NPM1mut AML pts and to investigate its prognostic and predictive impact on outcome, were presented at the 65th American Society of Hematology Annual Meeting and Exposition.
    • 13 Dec 2022 Final results presented at the 64th American Society of Hematology Annual Meeting and Exposition
    • 13 Dec 2022 Primary endpoint (Overall survival (OS) has not been met according to results presented at the 64th American Society of Hematology Annual Meeting and Exposition

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