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A Pilot Pharmacokinetic, Pharmacodynamic and Feasibility Study of Sorafenib in Combination With Cytarabine and Clofarabine in Patients With Refractory or Relapsed Hematologic Malignancies.

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Trial Profile

A Pilot Pharmacokinetic, Pharmacodynamic and Feasibility Study of Sorafenib in Combination With Cytarabine and Clofarabine in Patients With Refractory or Relapsed Hematologic Malignancies.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 09 Nov 2021

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At a glance

  • Drugs Sorafenib (Primary) ; Clofarabine; Cytarabine
  • Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia; Acute promyelocytic leukaemia; Myelodysplastic syndromes; Myeloproliferative disorders; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions
  • Acronyms RELHEM

    • Most Recent Events

    • 27 Aug 2019 Results assessing population pharmacokinetic modeling by using data from two studies (RELHEM and ANGIO1) published in the Clinical Cancer Research.
    • 10 Jul 2015 Status changed from recruiting to completed as reported by ClinicalTrials.gov record.
    • 12 Jan 2015 Planned End Date changed from 1 Jan 2015 to 1 Jun 2015 as per ClinicalTrials.gov record.

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