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An Open-Label, Dose-Escalation, Phase 1 Study Evaluating the Safety and Tolerability of Weekly Dosing of the Oral Form of MLN9708, a Second-Generation Proteasome Inhibitor, in Adult Patients With Relapsed and Refractory Multiple Myeloma

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Trial Profile

An Open-Label, Dose-Escalation, Phase 1 Study Evaluating the Safety and Tolerability of Weekly Dosing of the Oral Form of MLN9708, a Second-Generation Proteasome Inhibitor, in Adult Patients With Relapsed and Refractory Multiple Myeloma

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 14 Jan 2020

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At a glance

  • Drugs Ixazomib (Primary)
  • Indications Multiple myeloma
  • Focus Adverse reactions
  • Sponsors Millennium

Most Recent Events

  • 12 Aug 2017 Data from this and other trials (NCT00932698, NCT01217957, NCT01564537) was used to quantitatively characterize the benefit-risk profile of ixazomib in relapsed/refractory MM, results published in the Targeted Oncology
  • 13 Mar 2017 Results (n=755) of pooled analysis of (C16001,C16002,C16003,C16004,C16005,C16007,C16008,C16010,C16013,TB-MC010034) ten studies assessing pharmacokinetic analysis of Ixazomib published in the Clinical Pharmacokinetics.
  • 02 Apr 2016 Exposure safety-efficacy analysis (n=44) published in the Investigational New Drugs.

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