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VELVET (Veltuzumab various doses exploratory trial), a randomized, double blind, placebo controlled, multicentre, multinational phase II dose range finding trial in subjects with moderate to severe rheumatoid arthritis insufficiently controlled with either methotrexate alone or methotrexate plus anti-tumour necrosis factor biological treatment, comparing 3 different subcutaneous dosages of anti-CD20 monoclonal antibody veltuzumab to placebo as an add-on therapy to methotrexate.

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Trial Profile

VELVET (Veltuzumab various doses exploratory trial), a randomized, double blind, placebo controlled, multicentre, multinational phase II dose range finding trial in subjects with moderate to severe rheumatoid arthritis insufficiently controlled with either methotrexate alone or methotrexate plus anti-tumour necrosis factor biological treatment, comparing 3 different subcutaneous dosages of anti-CD20 monoclonal antibody veltuzumab to placebo as an add-on therapy to methotrexate.

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 09 Nov 2021

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At a glance

  • Drugs Veltuzumab (Primary) ; Methotrexate; Methotrexate
  • Indications Rheumatoid arthritis
  • Focus Adverse reactions; Biomarker; Therapeutic Use
  • Acronyms VELVET

Most Recent Events

  • 30 Oct 2012 This trial has been discontinued in Germany, Spain, Czech Republic, Hungary and suspended in United kingdom as reported by European Clinical Trials Database.
  • 01 Oct 2012 Status changed from active, no longer recruiting to discontinued as reported by ClinicalTrials.gov.
  • 04 May 2012 Company (Takeda Global Research and Development Center, Inc) added as reported by ClinicalTrials.gov.

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