A Randomised, Multicentre, Multinational Phase II Study to Evaluate Pertuzumab in Combination With Trastuzumab, Given Either Concomitantly or Sequentially With Standard Anthracycline-based Chemotherapy or Concomitantly With a Non-anthracycline-based Chemotherapy Regimen, as Neoadjuvant Therapy for Patients With Locally Advanced, Inflammatory or Early Stage HER2-positive Breast Cancer

Trial Profile

A Randomised, Multicentre, Multinational Phase II Study to Evaluate Pertuzumab in Combination With Trastuzumab, Given Either Concomitantly or Sequentially With Standard Anthracycline-based Chemotherapy or Concomitantly With a Non-anthracycline-based Chemotherapy Regimen, as Neoadjuvant Therapy for Patients With Locally Advanced, Inflammatory or Early Stage HER2-positive Breast Cancer

Completed
Phase of Trial: Phase II

Latest Information Update: 18 May 2018

At a glance

  • Drugs Pertuzumab (Primary) ; Carboplatin; Cyclophosphamide; Docetaxel; Epirubicin; Fluorouracil; Hormones; Trastuzumab
  • Indications Early breast cancer
  • Focus Adverse reactions
  • Acronyms TRYPHAENA
  • Sponsors Roche
  • Most Recent Events

    • 18 May 2018 Results (n=173) assessing associations between baseline TILs and baseline tumor gene expression published in the Journal of the National Cancer Institute
    • 07 Dec 2017 Results published in the European Journal of Cancer
    • 05 Jan 2017 Results of data from the safety populations of three trials (NEOSPHERE, CLEOPATRA and TRYPHAENA) published in the Annals of Oncology
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