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A Randomized Phase III, Double-blind, Placebo-controlled Multicenter Trial of Daily Everolimus in Combination With Trastuzumab and Vinorelbine, in Pretreated Women With HER2/Neu Over-expressing Locally Advanced or Metastatic Breast Cancer.

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Trial Profile

A Randomized Phase III, Double-blind, Placebo-controlled Multicenter Trial of Daily Everolimus in Combination With Trastuzumab and Vinorelbine, in Pretreated Women With HER2/Neu Over-expressing Locally Advanced or Metastatic Breast Cancer.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 08 Nov 2021

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At a glance

  • Drugs Everolimus (Primary) ; Trastuzumab; Vinorelbine
  • Indications Advanced breast cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms BOLERO-3
  • Sponsors Novartis Pharmaceuticals

    • Most Recent Events

    • 18 Apr 2016 Results of a pooled biomarker analysis form BOLERO-1 and BOLERO-3 trials (n=549) published in the Journal of Clinical Oncology
    • 12 Dec 2015 Results presented at the 38th Annual San Antonio Breast Cancer Symposium (n = 569).
    • 13 Oct 2015 Status changed from active, no longer recruiting to completed, according to ClinicalTrials.gov record.
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