Inhibition of Autophagy in Solid Tumors: A Phase I Pharmacokinetic and Pharmacodynamic Study of Hydroxychloroquine in Combination With the HDAC Inhibitor Vorinostat for the Treatment of Patients With Advanced Solid Tumors With an Expansion Study in Advanced Renal and Colorectal Cancer
Phase of Trial: Phase I
Latest Information Update: 23 Aug 2017
At a glance
- Drugs Hydroxychloroquine (Primary) ; Vorinostat (Primary)
- Indications Colorectal cancer; Renal cancer; Solid tumours
- Focus Adverse reactions
- 16 Aug 2017 Planned End Date changed from 1 Jul 2017 to 1 Sep 2018.
- 16 Aug 2017 Planned primary completion date changed from 1 Jul 2017 to 1 Jul 2018.
- 25 Apr 2017 Planned End Date changed from 1 Jan 2017 to 1 Jul 2017.