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A Phase 3b, Double-Blind, Randomized, 12-Week Efficacy and Safety Study Comparing the TAK-491 Plus Chlorthalidone Fixed-Dose Combination vs Olmesartan Medoxomil-Hydrochlorothiazide in Subjects With Moderate to Severe Hypertension

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Trial Profile

A Phase 3b, Double-Blind, Randomized, 12-Week Efficacy and Safety Study Comparing the TAK-491 Plus Chlorthalidone Fixed-Dose Combination vs Olmesartan Medoxomil-Hydrochlorothiazide in Subjects With Moderate to Severe Hypertension

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 08 Nov 2021

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At a glance

Most Recent Events

  • 04 Aug 2018 Results of two post hoc analyses (first pooled analysis: n= 1610; NCT00696241 and NCT00696436; second analysis: n=1020; NCT01033071) comparing effectiveness of azilsartan medoxomil (AZL-M) and the fixed-dose combination of AZL-M with chlorthalidone (AZL-M/CLD) versus the ARB olmesartan (OLM) and the OLM fixed-dose combination with hydrochlorothiazide (OLM/HCTZ) in blacks versus white patients with systemic hypertension, published in the American Journal of Cardiology.
  • 17 Jun 2013 Pooled analysis presented at the 23rd European Meeting on Hypertension.
  • 18 Jun 2012 Results published in Hypertension.

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