Trial Profile
A Phase 1 Dose Escalation Study of MLN8237, an Aurora A Kinase Inhibitor, in Adult Patients With Nonhematological Malignancies, Followed by a Phase 2 of MLN8237 in Lung, Breast, Head and Neck, or Gastroesophageal Malignancies.
Status:
Completed
Phase of Trial:
Phase I/II
Latest Information Update: 08 Nov 2021
Price :
$35
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At a glance
- Drugs Alisertib (Primary)
- Indications Advanced breast cancer; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer; Small cell lung cancer; Solid tumours
- Focus Adverse reactions; Biomarker; Therapeutic Use
- Sponsors Millennium; Takeda Oncology
- 11 Sep 2017 Results (n=671) of population PK analysis using patient data from 6 Phase 1, 1 Phase 1/2 and 3 Phase 2 clinical trials published in the British Journal of Clinical Pharmacology
- 14 Dec 2013 Phase II results for breast cancer patients presented at the 36th Annual San Antonio Breast Cancer Symposium.
- 28 Jun 2013 Planned end date changed from 1 Nov 2013 to 1 Jul 2013 as reported by ClinicalTrials.gov.