Trial Profile

Phase I/II clinical trial to assess the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase (PARP) -inhibitor, in relapsed and refractory chronic lymphocytic leukaemia patients with an 11q deletion or ATM mutation and relapsed/refractory patients with T-prolymphocytic leukaemia and mantle cell lymphoma.

Status: Completed

Phase of Trial: Phase I/II

Latest Information Update: 05 Apr 2022

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At a glance

Drugs Olaparib (Primary)
Indications Chronic lymphocytic leukaemia; Mantle-cell lymphoma; T-cell prolymphocytic leukaemia
Focus Therapeutic Use
Acronyms PICCLe

27 Feb 2016 Status changed from active, no longer recruiting to completed as per ISRCTN: Current Controlled Trials record.
06 Mar 2015 Status changed from recruiting to active, no longer recruiting, as reported by United Kingdom Clinical Research Network.
06 Nov 2013 Accrual to date is 20% according to United Kingdom Clinical Research Network.

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