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Phase I, Dose-ranging, Open-label, Study of a Single Administration of T-cells Add-back Depleted of Host Alloreactive Cells Using Theralux™ Therapy, Following Haploidentical Peripheral Blood Stem Cell Transplantation Submitted to CD34+ Cell Selection, in Patients With Severe Hematologic Malignancies

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Phase I, Dose-ranging, Open-label, Study of a Single Administration of T-cells Add-back Depleted of Host Alloreactive Cells Using Theralux™ Therapy, Following Haploidentical Peripheral Blood Stem Cell Transplantation Submitted to CD34+ Cell Selection, in Patients With Severe Hematologic Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 08 Nov 2021

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At a glance

  • Drugs T cell replacement therapy TH 9402 (Primary) ; Antithymocyte globulin; Fludarabine; Methylprednisolone; Thiotepa
  • Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Chronic myeloid leukaemia; Graft-versus-host disease; Multiple myeloma; Myelodysplastic syndromes; Myelofibrosis; Non-Hodgkin's lymphoma
  • Focus Adverse reactions; Proof of concept
  • Sponsors Kiadis Pharma

    • Most Recent Events

    • 19 Sep 2017 According to a Kiadis Pharma media release, results from this trial were presented at the 4th Cell and Gene Therapy Conference.
    • 03 Sep 2014 Results published in a Kiadis Pharma Media Release.
    • 29 Apr 2010 New trial record

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