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A Long-term, Multi-centre, International, Randomised Double-blind, Placebo-controlled Trial to Determine Liraglutide Effects on Cardiovascular Events

Trial Profile

A Long-term, Multi-centre, International, Randomised Double-blind, Placebo-controlled Trial to Determine Liraglutide Effects on Cardiovascular Events

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 19 Oct 2024

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At a glance

  • Drugs Liraglutide (Primary)
  • Indications Cardiovascular disorders; Type 2 diabetes mellitus
  • Focus Registrational; Therapeutic Use
  • Acronyms LEADER
  • Sponsors Novo Nordisk

Most Recent Events

  • 26 Jun 2023 Results using individual-level participant data from LEADER , SUSTAIN 6 and PIONEER 6 , comparing cardiovascular (CV) protective effect of liraglutide vs semaglutide in subjects with type 2 diabetes, presented at the 83rd Annual Scientific Sessions of the American Diabetes Association
  • 20 Jun 2022 Results assessing cardiovascular (CV) efficacy of liraglutide and semaglutide in patients with type 2 diabetes (T2D) and peripheral artery disease from LEADER and SUSTAIN-6 studies, published in the Diabetes, Obesity and Metabolism.
  • 14 Dec 2021 Results of pooled analysis from SUSTAIN 6 and LEADER, assessing assessed the effect of once-weekly semaglutide and once daily liraglutide on kidney outcomes in type 2 diabetes, published in the Circulation

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