Either you have JavaScript disabled or your browser does not support Javascript . To work properly, this page requires JavaScript to be enabled.
How to enable JavaScript in your browser?

A Pilot, Pharmacodynamic Correlate, Multi-Institutional Trial of Sirolimus in Combination With Chemotherapy (Mitoxantrone, Etoposide, Cytarabine) for the Treatment of High Risk, Acute Myelogenous Leukemia.

Next Previous
Trial Profile

A Pilot, Pharmacodynamic Correlate, Multi-Institutional Trial of Sirolimus in Combination With Chemotherapy (Mitoxantrone, Etoposide, Cytarabine) for the Treatment of High Risk, Acute Myelogenous Leukemia.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 06 Jun 2025

Price :
$35 *
Note:
  • Adis is an information provider.
  • Final gross price and currency may vary according to local VAT and billing address.
  • Your purchase entitles you to full access to the information contained in our trial profile at the time of purchase.
  • A link to download a PDF version of the trial profile will be included in your email receipt.

At a glance

  • Drugs Sirolimus (Primary) ; Cytarabine; Etoposide; Mitoxantrone
  • Indications Acute myeloid leukaemia
  • Focus Pharmacodynamics; Therapeutic Use

Most Recent Events

  • 02 Apr 2018 According to results of a combined analysis of the pilot (NCT00780104; n=15) and subsequent phase II (NCT01184898; n=36) study published in the Investigational New Drugs Journal, secondary endpoints for both studies included assessment of safety, overall survival and incidence of subsequent allogeneic transplantation.
  • 02 Apr 2018 Results of a combined analysis of the pilot (NCT00780104; n=15) and subsequent phase II (NCT01184898; n=36) study assessing the association between mTORC1 target inhibition in leukemic blasts and clinical response to a regimen combining sirolimus and MEC chemotherapy, published in the Investigational New Drugs Journal.
  • 19 Oct 2016 Status changed from active, no longer recruiting to completed.

You need to be a logged in or subscribed to view this content

Request demo (opens in a new window)
If your organization or you do not have a subscription, try one of the following: If your organization has a subscription, there are several access options, even while working remotely:
  • Working within your organization’s network
  • with username/password or try to via your institution
  • Persisted access using your organization’s identifier stored in your user browser for 90 days
Back to top