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Randomized Study Comparing Conventional Dose Treatment Using a Combination of Lenalidomide, Bortezomib and Dexamethasone to High-Dose Treatment With ASCT in the Initial Management of Myeloma in Patients up to 65 Years of Age

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Trial Profile

Randomized Study Comparing Conventional Dose Treatment Using a Combination of Lenalidomide, Bortezomib and Dexamethasone to High-Dose Treatment With ASCT in the Initial Management of Myeloma in Patients up to 65 Years of Age

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Mar 2023

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At a glance

  • Drugs Bortezomib (Primary) ; Dexamethasone (Primary) ; Lenalidomide (Primary) ; Melphalan
  • Indications Multiple myeloma
  • Focus Therapeutic Use
  • Acronyms IFM/DFCI 2009

Most Recent Events

  • 12 May 2022 Results of an analysis of a sub-study of IFM/DFCI 2009 cohort assessed the venous thromboembolism incidence, risk factors and risk score published in the Journal of Thrombosis and Haemostasis
  • 17 Jun 2021 Results of meta-analysis of randomized controlled trials (IFM 2009, EMN02/HOVON 95, RV-MM-EMN-441, RV-MM-PI-209 and FORTE), assessing association of HDT-AHCT with PFS in newly diagnosed high-risk myeloma, with overall survival being the secondary objective, presented at the 26th Congress of the European Haematology Association.
  • 14 Jan 2021 Results of a pooled analysis (of data extracted from NCT01712789, NCT02773030, NCT01421524, NCT01191060 studies and Myeloma Genome Project) assessing multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma published in the Blood

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