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A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous LY2127399 in Patients With Systemic Lupus Erythematosus (SLE).

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Trial Profile

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous LY2127399 in Patients With Systemic Lupus Erythematosus (SLE).

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 12 Dec 2022

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At a glance

  • Drugs Tabalumab (Primary)
  • Indications Systemic lupus erythematosus
  • Focus Pharmacogenomic; Registrational; Therapeutic Use
  • Acronyms ILLUMINATE-2
  • Sponsors Eli Lilly and Company

    • Most Recent Events

    • 09 Nov 2021 Results assessing Lupus Multivariable Outcome Score (LuMOS) to optimize discrimination between outcomes of actively treated patients versus those randomized to placebo from ILLUMINATE-1 and ILLUMINATE-2 trials, presented at the ACR Convergence 2021.
    • 05 Jun 2021 Data from two phase 3 trials (NCT01196091 and NCT01205438) used to devise a deep learning method uncovers novel pathway associations in systemic lupus erythematosus presented at the 22nd Annual Congress of the European League Against Rheumatism
    • 12 Feb 2021 Results from Two Phase III Randomized Trials (NCT01205438 and NCT01196091) published in the Rheumatology

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