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A randomized, double-blind, parallel group placebo-controlled study of the safety and reduction of signs and symptoms during treatment with tocilizumab (TCZ) [Actemra; Roche] versus placebo in patients with ankylosing spondylitis who have had an inadequate response to previous TNF [tumour necrosis factor] antagonist therapy

Trial Profile

A randomized, double-blind, parallel group placebo-controlled study of the safety and reduction of signs and symptoms during treatment with tocilizumab (TCZ) [Actemra; Roche] versus placebo in patients with ankylosing spondylitis who have had an inadequate response to previous TNF [tumour necrosis factor] antagonist therapy

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 03 Aug 2022

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At a glance

  • Drugs Tocilizumab (Primary)
  • Indications Ankylosing spondylitis
  • Focus Therapeutic Use
  • Acronyms BUILDER-2
  • Sponsors Roche

Most Recent Events

  • 31 Jul 2022 This trial has been completed in Spain (End Date: 28 Dec 2011), according to European Clinical Trials Database record.
  • 13 Jun 2013 Results published in the Annals of the Rheumatic Diseases.
  • 08 Apr 2013 New source identified and integrated (Clinical Trials Registry - India: CTRI2011-04-001692).

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