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A Multi-Center Randomized Phase III Study Evaluating 4 Cycles of Docetaxel, Doxorubicin and Cyclophosphamide Versus 4 Cycles of Vinorelbine and Capecitabine in Patients Not Sufficiently Responding to 2 Cycles of TAC and 4 Cycles of TAC Versus 6 Cycles of TAC in Patients Sufficiently Responding to 2 Cycles of TAC as Preoperative Treatment of Locally Advanced or Operable Primary Breast Cancer

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Trial Profile

A Multi-Center Randomized Phase III Study Evaluating 4 Cycles of Docetaxel, Doxorubicin and Cyclophosphamide Versus 4 Cycles of Vinorelbine and Capecitabine in Patients Not Sufficiently Responding to 2 Cycles of TAC and 4 Cycles of TAC Versus 6 Cycles of TAC in Patients Sufficiently Responding to 2 Cycles of TAC as Preoperative Treatment of Locally Advanced or Operable Primary Breast Cancer

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Feb 2023

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At a glance

  • Drugs Capecitabine (Primary) ; Cyclophosphamide (Primary) ; Docetaxel (Primary) ; Doxorubicin (Primary) ; Vinorelbine (Primary)
  • Indications Advanced breast cancer; Early breast cancer
  • Focus Pharmacogenomic; Therapeutic Use
  • Acronyms GeparTrio

Most Recent Events

  • 14 Dec 2019 Results (N= 15,457), a metanalysis of prospective randomized trials assessing efficacy of Capecitabine as a part of neo adjuvant or adjuvant therapy in patients with early breast cancer, presented at the 42nd Annual San Antonio Breast Cancer Symposium
  • 20 Apr 2016 Results (pooled analysis of this and other study) assessing genomic alterations in pretherapeutic core biopsies presented at the 107th Annual Meeting of the American Association for Cancer Research.
  • 10 Dec 2011 Results presented at the 34th Annual San Antonio Breast Cancer Symposium.

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