Trial Profile
A Randomized, Double-blind, Parallel Group Study of Safety and the Effect on Clinical Outcome of Tocilizumab Subcutaneous (sc) Versus Placebo sc in Combination With Traditional Disease Modifying Anti-rheumatic Drugs (DMARDs) in Patients With Moderate to Severe Active Rheumatoid Arthritis
Status:
Completed
Phase of Trial:
Phase III
Latest Information Update: 07 Oct 2021
Price :
$35
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At a glance
- Drugs Tocilizumab (Primary) ; Disease-modifying antirheumatics
- Indications Rheumatoid arthritis
- Focus Registrational; Therapeutic Use
- Acronyms BREVACTA
- Sponsors Roche
- 05 Jun 2021 Results of a pooled analysis comparing the the effects on disease activity at week 24, when the dosing schedule of TCZ-SC was escalated from q2w to qw, in patients who did not achieve LDA (DAS28-ESR > 3.2) at week 12 in COMP-ACT with patients who, despite not achieving LDA, continued TCZ-SC qw in SUMMACTA and q2w in BREVACTA presented at the 22nd Annual Congress of the European League Against Rheumatism
- 26 Aug 2020 Results of a pooled analysis from twelve phase 3 and 4 clinical trials: ACT-RAY, ACT-STAR, ACT-SURE, ADACTA, AMBITION, BREVACTA, COMP-ACT, LITHE, OPTION, ROSE, SUMMACTA and TOWARD assessing predictors of response, including demographics, disease characteristics at baseline published in the Rheumatology
- 06 Jun 2020 Results of pooled analysis from seven studies (OPTION, RADIATE, TOWARD, LITHE, ACT-RAY, ADACTA and BREVACTA) presented at the 21st Annual Congress of the European League Against Rheumatism.