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A Randomized, Double-Blind Study of the Safety and Efficacy of GSK1349572 Plus Abacavir/Lamivudine Fixed-Dose Combination Therapy Administered Once Daily Compared to Atripla Over 96 Weeks in HIV-1 Infected Antiretroviral Therapy Naive Adult Subjects

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A Randomized, Double-Blind Study of the Safety and Efficacy of GSK1349572 Plus Abacavir/Lamivudine Fixed-Dose Combination Therapy Administered Once Daily Compared to Atripla Over 96 Weeks in HIV-1 Infected Antiretroviral Therapy Naive Adult Subjects

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 31 Aug 2023

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At a glance

  • Drugs Abacavir/dolutegravir/lamivudine (Primary) ; Dolutegravir (Primary) ; Efavirenz/emtricitabine/tenofovir-disoproxil-fumarate
  • Indications HIV-1 infections
  • Focus Registrational; Therapeutic Use
  • Acronyms SINGLE
  • Sponsors ViiV Healthcare

    • Most Recent Events

    • 08 Oct 2020 Results of pooled analysis assessing the efficacy and safety profile of the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) relative to comparator ART in PLWH naive to ART by age group from four phase III/IIIb, presented at the 15th International Congress on Drug Therapy and HIV Infection
    • 30 Apr 2019 Results of post hoc analysis using VL data obtained from the timepoints shared by A5353, SPRING 1 and SINGLE trial published in the Journal of Antimicrobial Chemotherapy
    • 31 Oct 2018 Results comparing viral decay with dolutegravir plus lamivudine versus dolutegravir-based triple therapy using data from A5353, SPRING-1 and SINGLE (n=588) presented at the 14th International Congress on Drug Therapy and HIV Infection

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