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Phase I Pharmacodynamic and "High Content" Study of the Gamma-Secretase Inhibitor RO4929097 in Patients With Recurrent Malignant Gliomas (MGs) Targeting p75NTR to Inhibit Brain Tumor Initiating Cells (BTICs) and Recurrent Invasive Gliomas.

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Trial Profile

Phase I Pharmacodynamic and "High Content" Study of the Gamma-Secretase Inhibitor RO4929097 in Patients With Recurrent Malignant Gliomas (MGs) Targeting p75NTR to Inhibit Brain Tumor Initiating Cells (BTICs) and Recurrent Invasive Gliomas.

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 17 Sep 2021

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At a glance

  • Drugs RG 4733 (Primary)
  • Indications Astrocytoma; Glioblastoma; Glioma; Oligodendroglioma
  • Focus Adverse reactions; Biomarker; Pharmacokinetics; Therapeutic Use

    • Most Recent Events

    • 06 Feb 2013 Status changed from completed to discontinued as reported by ClinicalTrials.gov.
    • 02 Feb 2012 Actual end date (Feb 2012) added as reported by ClinicalTrials.gov.
    • 02 Feb 2012 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.

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