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A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women With Node- Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer

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A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women With Node- Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 24 Mar 2025

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At a glance

  • Drugs Trastuzumab (Primary) ; Cyclophosphamide; Docetaxel; Doxorubicin; Paclitaxel
  • Indications Adenocarcinoma; Early breast cancer; HER2 negative breast cancer
  • Focus Therapeutic Use

    • Most Recent Events

    • 06 Aug 2024 Planned End Date changed from 12 Jul 2024 to 12 Jul 2025.
    • 10 Dec 2019 Results assessing whether the addition of trastuzumab to adjuvant chemotherapy improve invasive disease free survival in patients with HER2 negative breast cancer were published in the Journal of Clinical Oncology
    • 09 Dec 2017 Results presented at the 40th Annual San Antonio Breast Cancer Symposium

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