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An International Randomised Controlled Trial to Establish the Effects of Low-dose rtPA and the Effects of Early Intensive Blood Pressure Lowering in Patients With Acute Ischaemic Stroke

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An International Randomised Controlled Trial to Establish the Effects of Low-dose rtPA and the Effects of Early Intensive Blood Pressure Lowering in Patients With Acute Ischaemic Stroke

Status: Completed
Phase of Trial: Phase III/IV

Latest Information Update: 19 Nov 2024

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At a glance

  • Drugs Alteplase (Primary) ; Antihypertensives; Labetalol; Nitroglycerin
  • Indications Stroke
  • Focus Therapeutic Use
  • Acronyms ENCHANTED

    • Most Recent Events

    • 03 Feb 2021 Results of post hoc analysis assessing differential efficacy and safety of low versus standard dose intravenous alteplase for lacunar versus non-lacunar acute ischemic stroke, published in the Neurology
    • 01 Jul 2020 Results (N=293) assessing the factors associated with fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-HAs) on magnetic resonance imaging and their prognostic significance in thrombolysis-treated patients with acute ischemic stroke from the alteplase-dose arm published in the Stroke
    • 21 Feb 2020 Results (n=2196) of analysis from two clinical studies: ENCHANTED and INTERACT2 assessing regional variations in early BP management in acute stroke patients were presented at the International Stroke Conference 2020

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