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Pilot Study of Redirected Autologous T-cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patient With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma

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Pilot Study of Redirected Autologous T-cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patient With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 31 Mar 2023

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At a glance

  • Drugs Tisagenlecleucel (Primary)
  • Indications B-cell prolymphocytic leukaemia; Chronic lymphocytic leukaemia; Follicular lymphoma; Leukaemia; Lymphoma; Mantle-cell lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions

    • Most Recent Events

    • 09 Dec 2019 Results of patients with acute lymphoblastic leukemia received CTL019 as single or fractionated dosing in one of the two clinical trials: (n=7; NCT01029366 and n=42; NCT02030847) evaluating adaptive dosing schemes with optimizing safety while preserving efficacy were published in the Journal of Clinical Oncology
    • 04 Dec 2018 Results assessing safety of CAR T cells in chronic lymphocytic lymphoma patients, presented at the 60th Annual Meeting and Exposition of the American Society of Hematology.
    • 12 Sep 2017 Results of this and other trials (NCT01747486 and NCT01626495) published in the Blood

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