A Phase I/II Study of the ALK Inhibitor CH5424802/RO5424802 in Patients with ALK-Rearranged Non-Small Cell Lung Cancer Previously Treated with Chemotherapy and Crizotinib

Trial Profile

A Phase I/II Study of the ALK Inhibitor CH5424802/RO5424802 in Patients with ALK-Rearranged Non-Small Cell Lung Cancer Previously Treated with Chemotherapy and Crizotinib

Completed
Phase of Trial: Phase I/II

Latest Information Update: 24 Jul 2018

At a glance

  • Drugs Alectinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms Study 1
  • Sponsors Roche
  • Most Recent Events

    • 05 Jun 2018 Results (n=207) of an exposure-response analysis of alectinib in crizotinib-resistant ALK-positive non-small cell lung cancer patients using final pooled phase II OS and safety data (NCT01801111 and NCT01871805), presented at the 54th Annual Meeting of the American Society of Clinical Oncology.
    • 05 Jun 2018 Results of a pooled analysis of NP28673 and NP28761 trials (n=225) assessing the survival and safety, presented at the 54th Annual Meeting of the American Society of Clinical Oncology
    • 16 Nov 2017 Results of exploratory analysis evaluated cumulative incidence rates (CIRs) of CNS and non-CNS progression in alectinib-treated patients in the two pivotal phase II studies (NCT01801111 and NCT01871805), were published in the British Journal of Cancer.
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