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Efficacy and Safety of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia

Trial Profile

Efficacy and Safety of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 Sep 2022

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At a glance

  • Drugs CYD TDV (Primary)
  • Indications Dengue
  • Focus Registrational; Therapeutic Use
  • Sponsors Sanofi Pasteur
  • Most Recent Events

    • 03 Sep 2022 Results assessing integrated the nAb and sequence data types by assessing neutralizing antibody titers as a correlate of sequence-specific virologically-confirmed dengue separately in the vaccine arm and in the placebo arm, published in the Vaccine.
    • 26 Jun 2021 Results investigating how natural infection-elicited nAbs are related to long-term instantaneous risk of hospitalized dengue from two trials (CYD14 and CYD15) published in the Journal of Infectious Diseases
    • 04 Apr 2021 Results of post-hoc analysis assessing hospitalized and severe VCD cases over the entire six-year follow-up of (two Phase III trials (CYD14 [NCT01373281] and CYD15 [NCT01374516]) and the Phase IIb trial (CYD23/CYD57 [NCT00842530/NCT01983553]) published in the Clinical Infectious Diseases

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