Trial Profile
A Randomized, Placebo- and Ezetimibe-controlled, Dose-ranging Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C in Hypercholesterolemic Subjects With a 10-year Framingham Risk Score of 10% or Less
Status:
Completed
Phase of Trial:
Phase II
Latest Information Update: 07 Nov 2021
Price :
$35
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At a glance
- Drugs Evolocumab (Primary) ; Ezetimibe
- Indications Hypercholesterolaemia
- Focus Therapeutic Use
- Acronyms MENDEL
- Sponsors Amgen
- 01 Mar 2017 Results (n=6026) of pooled safety analysis of this and other eleven trials (LAPLACE-TIMI 57,RUTHERFORD,GAUSS,MENDEL,YUKAWA,LAPLACE-2,RUTHERFORD-2,GAUSS-2,MENDEL-2,DISCARTES,THOMAS-1,THOMAS-2) published in the Circulation.
- 20 Nov 2013 Extension study results presented at the 86th Annual Scientific Sessions of the American Heart Association.
- 04 Sep 2013 Pooled tolerability analysis presented at the ESC Congress 2013: Annual Congress of the European Society of Cardiology.