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LAPLACE TIMI 57 - A Double-blind, Randomized, Placebo-controlled, Multicenter, Dose-ranging Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C in Combination With HMG-CoA Reductase Inhibitors in Hypercholesterolemic Subjects

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Trial Profile

LAPLACE TIMI 57 - A Double-blind, Randomized, Placebo-controlled, Multicenter, Dose-ranging Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C in Combination With HMG-CoA Reductase Inhibitors in Hypercholesterolemic Subjects

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Evolocumab (Primary) ; HMG-CoA reductase inhibitors
  • Indications Hypercholesterolaemia
  • Focus Therapeutic Use
  • Acronyms LAPLACE-TIMI-57
  • Sponsors Amgen

    • Most Recent Events

    • 01 Mar 2017 Results (n=6026) of pooled safety analysis of this and other eleven trials (LAPLACE-TIMI 57,RUTHERFORD,GAUSS,MENDEL,YUKAWA,LAPLACE-2,RUTHERFORD-2,GAUSS-2,MENDEL-2,DISCARTES,THOMAS-1,THOMAS-2) published in the Circulation.
    • 04 Sep 2013 Pooled tolerability analysis presented at the ESC Congress 2013: Annual Congress of the European Society of Cardiology.
    • 04 Sep 2013 Results from a pooled analysis presented at the ESC Congress 2013: Annual Congress of the European Society of Cardiology.

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