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A Phase 3, Randomized, Double-blind, Controlled Trial of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer

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A Phase 3, Randomized, Double-blind, Controlled Trial of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Cabozantinib (Primary) ; Mitoxantrone; Prednisone
  • Indications Bone metastases; Prostate cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms COMET-2
  • Sponsors Exelixis

    • Most Recent Events

    • 10 Feb 2018 Results (n=1147) of retrospective analysis of a combined dataset of COMET-1 and COMET-2 trials identifying a benefit in subsets of patients based on prognostic risk factors presented at the 2018 Genitourinary Cancers Symposium
    • 19 Feb 2015 Status changed from active, no longer recruiting to discontinued as reported by ClinicalTrials.gov
    • 01 Dec 2014 Results published in an Exelixis media release.

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