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A Phase 3, Randomized, Double-blind, Controlled Study of Cabozantinib (XL184) Versus Prednisone in Metastatic Castration-resistant Prostate Cancer Patients Who Have Received Prior Docetaxel and Prior Abiraterone or MDV3100

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A Phase 3, Randomized, Double-blind, Controlled Study of Cabozantinib (XL184) Versus Prednisone in Metastatic Castration-resistant Prostate Cancer Patients Who Have Received Prior Docetaxel and Prior Abiraterone or MDV3100

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 12 Dec 2022

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At a glance

  • Drugs Cabozantinib (Primary) ; Prednisone
  • Indications Prostate cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms COMET-1
  • Sponsors Exelixis

    • Most Recent Events

    • 10 Feb 2018 Results (n=1147) of retrospective analysis of a combined dataset of COMET-1 and COMET-2 trials identifying a benefit in subsets of patients based on prognostic risk factors presented at the 2018 Genitourinary Cancers Symposium
    • 06 Jun 2017 Results assessing a week 13 Circulating tumor cell prostate-specific antigen (PSA) endpoint relative to baseline in 5 prospective randomized phase 3 registration trials (n=5912, COU-AA-301, AFFIRM, ELM-PC-5, ELM-PC-4 and COMET-1 trials) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology
    • 11 Jul 2016 Results published in the Journal of Clinical Oncology (2016).

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