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A 2-arm, Prospective, Randomized, Controlled, Open-label, 12 Month Phase III Trial to Evaluate the Efficacy Regarding Renal Function of Everolimus in Combination With a Centre Specific Standard Immunosuppressive Regimen Consisting of CNI, Purinantagonists and Steroids Versus a Standard Triple Immunosuppressive Regimen in Lung Transplant Recipients

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Trial Profile

A 2-arm, Prospective, Randomized, Controlled, Open-label, 12 Month Phase III Trial to Evaluate the Efficacy Regarding Renal Function of Everolimus in Combination With a Centre Specific Standard Immunosuppressive Regimen Consisting of CNI, Purinantagonists and Steroids Versus a Standard Triple Immunosuppressive Regimen in Lung Transplant Recipients

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 17 Mar 2022

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At a glance

  • Drugs Everolimus (Primary) ; Ciclosporin; Corticosteroids; Mycophenolic acid; Tacrolimus
  • Indications Lung transplant rejection
  • Focus Pharmacodynamics
  • Acronyms 4EVERLUNG
  • Sponsors Novartis Pharmaceuticals

Most Recent Events

  • 08 Mar 2022 Results assessing five-year outcome of an early Everolimus-based quadruple immunosuppression in lung transplant recipients published in the Transplantation
  • 07 Jan 2019 Results published in the American Journal of Transplantation
  • 06 Jun 2018 Primary endpoint has been met. (Renal function measured by calculated Glomerular Filtration Rate (cGFR) Using Modification of Diet in Renal Disease (MDRD) Formula at 12 months) as per results presented at the 2018 American Transplant Congress

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