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An exploratory phase IIa study to evaluate the safety and immunological effects of intravenous interferon beta-1a (IFN beta-1a, Rebif) therapy in the induction of tolerance to IFN beta in MS patients with neutralising antibodies (NAbs) to subcutaneous IFN beta-1a (Rebif or Avonex).

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Trial Profile

An exploratory phase IIa study to evaluate the safety and immunological effects of intravenous interferon beta-1a (IFN beta-1a, Rebif) therapy in the induction of tolerance to IFN beta in MS patients with neutralising antibodies (NAbs) to subcutaneous IFN beta-1a (Rebif or Avonex).

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 31 Oct 2011

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At a glance

  • Drugs Interferon beta-1a (Primary) ; Mitoxantrone (Primary)
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Pharmacodynamics

Most Recent Events

  • 02 Aug 2011 New trial record

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