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Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacodynamic, and Pharmacokinetic Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Given Intravenously to Patients With Advanced Solid Tumors.

Trial Profile

Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacodynamic, and Pharmacokinetic Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Given Intravenously to Patients With Advanced Solid Tumors.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 Oct 2017

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At a glance

  • Drugs Hyaluronidase (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Halozyme Therapeutics
  • Most Recent Events

    • 26 Sep 2017 According to results published in the British Journal of Cancer, the study protocol was amended with a change of starting dose from 50ugkg-1 dose to 0.5ugkg-1 dose twice weekly.Later on the schedule was adjusted to every 21 days.
    • 26 Sep 2017 Results published in the British Journal of Cancer.
    • 01 Nov 2012 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
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