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Phase II Multicentric Randomized Trial, Evaluating the Best Protocol of Chemotherapy, Associated With Targeted Therapy According to the Tumor KRAS Status, in Metastatic Colorectal Cancer (CCRM) Patients With Initially Non-resectable Hepatic Metastases

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Phase II Multicentric Randomized Trial, Evaluating the Best Protocol of Chemotherapy, Associated With Targeted Therapy According to the Tumor KRAS Status, in Metastatic Colorectal Cancer (CCRM) Patients With Initially Non-resectable Hepatic Metastases

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 13 Jan 2022

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At a glance

  • Drugs Bevacizumab (Primary) ; Cetuximab (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary) ; Levofolinic acid (Primary) ; Oxaliplatin (Primary) ; Granulocyte colony-stimulating factors
  • Indications Adenocarcinoma; Colorectal cancer; Liver metastases
  • Focus Pharmacogenomic; Therapeutic Use
  • Acronyms METHEP 2; PRODIGE-14; UNICANCER PRODIGE-14

    • Most Recent Events

    • 06 Jan 2022 Primary endpoint (The main objective is to compare resection rates (R0 or R1) for hepatic metastases) has not been met as per results published in the British Journal of Cancer
    • 06 Jan 2022 Results published in the British Journal of Cancer
    • 05 Mar 2013 Actual initiation date changed from 1 Nov 2010 to 1 Feb 2011 as reported by ClinicalTrials.gov.

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