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A Phase 1, Open-label, Dose-escalation, Safety and Pharmacokinetic Study of CDX-1127 in Patients With Selected Refractory or Relapsed Hematologic Malignancies or Solid Tumors

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Trial Profile

A Phase 1, Open-label, Dose-escalation, Safety and Pharmacokinetic Study of CDX-1127 in Patients With Selected Refractory or Relapsed Hematologic Malignancies or Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Varlilumab (Primary)
  • Indications Adenocarcinoma; B-cell lymphoma; Burkitt's lymphoma; Chronic lymphocytic leukaemia; Colorectal cancer; Malignant melanoma; Mantle-cell lymphoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer; Renal cell carcinoma; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Celldex Therapeutics Inc

    • Most Recent Events

    • 11 Aug 2017 Planned End Date changed from 1 Dec 2016 to 1 Dec 2017.
    • 02 May 2017 Results (n=56) of ealuation of patients with solid tumours, published in the Journal of Clinical Oncology
    • 05 Jan 2016 Planned End Date changed from 1 Dec 2015 to 1 Dec 2016 as reported by ClinicalTrials.gov record.

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