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A Phase 2 Multicenter, Randomized, Placebo- and Active-Comparator-Controlled, Dose-Ranging Trial to Evaluate CNTO 1959 for the Treatment of Subjects With Moderate to Severe Plaque-type Psoriasis (X-PLORE)

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Trial Profile

A Phase 2 Multicenter, Randomized, Placebo- and Active-Comparator-Controlled, Dose-Ranging Trial to Evaluate CNTO 1959 for the Treatment of Subjects With Moderate to Severe Plaque-type Psoriasis (X-PLORE)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 17 Apr 2023

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At a glance

  • Drugs Guselkumab (Primary) ; Adalimumab
  • Indications Plaque psoriasis
  • Focus Therapeutic Use
  • Acronyms X-PLORE
  • Sponsors Janssen Research & Development

Most Recent Events

  • 06 Apr 2023 Results of pooled analysis from Phase 2/3 studies (X-PLORE, VOYAGE 1, VOYAGE 2, NAVIGATE, ORION, ECLIPSE, Japan registration) assessing guselkumab safety in patients with psoriasispublished in the British Journal of Dermatology
  • 17 Jan 2018 Results (n=1459) of pooled data from (VOYAGE 1, X-PLORE and VOYAGE 2) assessing efficacy and safety of guselkumab for the treatment of moderate to severe psoriasis, were published in the Journal of Clinical Pharmacology.
  • 25 Nov 2016 According to a Janssen media release, the company has submitted a Marketing Authorisation Application to the European Medicines Agency (EMA) seeking approval of guselkumab for the treatment of adults living with moderate to severe plaque psoriasis. Data from three phase III studies (VOYAGE 1, VOYAGE 2, NAVIGATE) and a phase II study (X-PLORE8) supported the application.

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