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A Randomised, Double-blind, Parallel-group, Active-controlled, Flexible Dose Study Evaluating the Effects of [Vortioxetine] Lu AA21004 Versus Agomelatine in Adult Patients Suffering From Major Depressive Disorder With Inadequate Response to Antidepressant Treatment.

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Trial Profile

A Randomised, Double-blind, Parallel-group, Active-controlled, Flexible Dose Study Evaluating the Effects of [Vortioxetine] Lu AA21004 Versus Agomelatine in Adult Patients Suffering From Major Depressive Disorder With Inadequate Response to Antidepressant Treatment.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 28 Mar 2023

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At a glance

  • Drugs Vortioxetine (Primary) ; Agomelatine
  • Indications Major depressive disorder
  • Focus Registrational; Therapeutic Use
  • Acronyms REVIVE
  • Sponsors Lundbeck A/S
  • Most Recent Events

    • 01 May 2023 Results of pooled analysis from NCT01140906, NCT01153009, NCT01163266, NCT01255787, NCT01488071, published in the Journal of Affective Disorders
    • 24 May 2017 Results assessing the overall performance priority the antidepressants: vortioxetine, agomelatine and venlafaxine XR in patients from two randomised trials (SOLUTION and REVIVE), presented at the 22nd Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research
    • 20 May 2015 Results comparing vortioxetine and other antidepressants presented at the 20th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research.
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