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A Phase II Trial of HKI-272 (Neratinib), Neratinib and Capecitabine, and Ado-Trastuzumab Emtansine for Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer and Brain Metastases

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Trial Profile

A Phase II Trial of HKI-272 (Neratinib), Neratinib and Capecitabine, and Ado-Trastuzumab Emtansine for Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer and Brain Metastases

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 24 May 2024

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At a glance

  • Drugs Neratinib (Primary) ; Capecitabine; Trastuzumab emtansine
  • Indications Advanced breast cancer; Brain metastases; HER2 positive breast cancer; Male breast cancer
  • Focus Therapeutic Use

    • Most Recent Events

    • 25 May 2024 Planned End Date changed from 1 Dec 2023 to 1 Dec 2024.
    • 07 Dec 2022 According to a Puma Biotechnology media release, results from the trial were presented by Rachel A Freedman, MD, MPH, Breast Oncology Center, Susan F. Smith Center for Women's Cancers, Dana Farber Cancer Institute, at Spotlight Poster Session 7 at the 2022 San Antonio Breast Cancer Symposium.
    • 05 May 2022 According to a Puma Biotechnology media release, the company expects to report the data from Cohort 4B and 4C of this study in the H2 2022.

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